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11. 10, the axon is predominantly oriented parallel to the lines of electrical force and hence is parallel to the ﬂow of electrical charges, so those parts of the axon would not be excited. However, the axon has a small S-shaped curve. On this small curve, the neuronal membrane is perpendicular to the lines of electrical force, so electrical charges may accumulate and may lead to depolarization of the neuronal membrane, initiating an action potential that will be conducted through the remainder of the axon.
DBS uses pulses of electrical energy by varying the amount of electrical current or voltage over time (although the maximum electrical current or voltage is kept constant). Consequently, impedance is the more appropriate measure of the opposition to the ﬂow of electrical current. You can also adjust the amount of water coming out of the hose by changing the water pressure through raising or lowering the height of the water tank. In this case, the water pressure corresponds to electromotive force or voltage, which corresponds to the force that moves the electrical charges, and it is measured in volts (V).
As a result, the inside of the neuron has negative voltage relative to the outside. 1 Sorting out DBS and Pharmacotherapy Although most patients with Parkinson’s disease who have undergone STN DBS can substantially reduce their medications, few are able to discontinue them. Consequently, you must manage the postoperative pharmacology as well as the DBS, especially in patients who receive beneﬁt from both therapies, such as patients with Parkinson’s disease. In the case of Parkinson’s disease, when DBS proves diﬃcult to optimize, many providers resort to pharmacotherapy.