Download Biological Research on Addiction. Comprehensive Addictive by Peter M. Miller PDF

By Peter M. Miller

ISBN-10: 0123983355

ISBN-13: 9780123983350

Biological study on Addiction examines the neurobiological mechanisms of drug use and drug habit, describing how the mind responds to addictive elements in addition to the way it is laid low with medications of abuse. The book's 4 major sections study behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.

This quantity is principally powerful in providing present wisdom at the key neurobiological and genetic components in an individual’s susceptibility to drug dependence, in addition to the methods wherein a few contributors continue from informal drug use to drug dependence.

Biological examine on Addiction is one in every of 3 volumes comprising the 2,500-page sequence, Comprehensive Addictive Behaviors and Disorders. This sequence presents the main entire selection of present wisdom on addictive behaviors and problems up to now. in brief, it's the definitive reference paintings on addictions.

  • Each article offers word list, complete references, instructed readings, and a listing of net resources
  • Edited and authored through the leaders within the box worldwide – the broadest, so much professional assurance available
  • Discusses the genetic foundation of addiction
  • Covers uncomplicated technological know-how study from numerous animal studies

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Extra info for Biological Research on Addiction. Comprehensive Addictive Behaviors and Disorders, Volume 2

Sample text

The use of sugar such as sucrose should be now taken with caution since numerous studies have shown that it can share some properties with drugs of abuse and is able to greatly influence the motivation for drug self-administration (such as for cocaine). Other studies are often using a forced paradigm with nutritionally complete control diet containing alcohol as their source of food and fluid. A major limitation of these models is that alcohol preference alone reflects controlled alcohol intake and not uncontrolled intake (loss of control) as expected when studying addiction.

Numerous studies involving social separation, either by early separation from a mother or by complete isolation, demonstrated elevated alcohol preference or intake. The availability of technology that allows for introducing targeted genetic modifications in model organisms has greatly contributed to our understanding of specific gene function. In the mouse, homologous recombination in embryonic stem (ES) cells has proven to be a powerful tool for generating genetic knockouts. In rat, gene knockout technology using homologous recombination approaches is still not available, due to the lack of pluripotent ES cells.

Drinking in larger amounts or over a longer period of time than was intended 2. Persistent desire and/or unsuccessful efforts to cut down or control use 3. A great deal of time spent in activities necessary to obtain alcohol, drinking, or recovering from its effects 4. Important social, occupational, or recreational activities given up or reduced because of drinking 5. Continued drinking despite knowledge of having a persistent or recurrent physical or psychological problem that is caused or exacerbated by drinking 6.

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